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Most cancers displayed weak to moderate nuclear positivity with additional cytoplasmic staining in few cases. Cases of squamous cell carcinomas, stomach and pancreatic cancers were strongly stained. Several lymphomas were negative.
Most cancer cells displayed strong nuclear and cytoplasmic positivity. Lymphomas and renal cancers generally showed weak to moderate staining.
GENE INFORMATION
Gene name
DNAJB1 (HGNC Symbol)
Synonyms
Hsp40, HSPF1, RSPH16B, Sis1
Description
DnaJ (Hsp40) homolog, subfamily B, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]