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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TRIM21
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TRIM21

Gene description

Tripartite motif containing 21

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA005673 , CAB004566
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PROGNOSTIC SUMMARY

Prognostic marker in thyroid cancer (favourable), breast cancer (favourable) and liver cancer (unfavourable).
Thyroid cancer p<0.001
Breast cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

HPA005673
CAB004566

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate to strong cytoplasmic and/or membranous staining. Several squamous cell carcinomas displayed strong nuclear and cytoplasmic staining. Hepatocellular carcinomas along with most gliomas, melanomas, lymphomas, renal and testicular cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed weak to moderate cytoplasmic immunoreactivity. Several endometrial, testicular and renal cancers were negative.

GENE INFORMATION

Gene name

TRIM21 (HGNC Symbol)

Synonyms

RNF81, Ro/SSA, RO52, SSA1

Description

Tripartite motif containing 21 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

4384897 - 4393696

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132109 (version 83.38)

Entrez gene

6737

UniProt

P19474 (UniProt - Evidence at protein level)

neXtProt

NX_P19474

Antibodypedia

TRIM21 antibodies

PROTEIN BROWSER

TRIM21-001
TRIM21-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIM21-001
ENSP00000254436
ENST00000254436
P19474 [Direct mapping]
E3 ubiquitin-protein ligase TRIM21
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006513 [protein monoubiquitination]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031648 [protein destabilization]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032897 [negative regulation of viral transcription]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045787 [positive regulation of cell cycle]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051865 [protein autoubiquitination]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070206 [protein trimerization]
GO:0090086 [negative regulation of protein deubiquitination]
GO:1902187 [negative regulation of viral release from host cell]
Show all
475 aa
54.2 kDa
No 0
TRIM21-003
ENSP00000434053
ENST00000533692
H0YDP8 [Direct mapping]
E3 ubiquitin-protein ligase TRIM21
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
90 aa
10.1 kDa
No 0

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