Expression of LRRC41 in cancer - Summary - The Human Protein Atlas

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LRRC41

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC41
Gene description	Leucine rich repeat containing 41
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA051941
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051941

GENE INFORMATION
Gene name	LRRC41 (HGNC Symbol)
Synonyms	MUF1
Description	Leucine rich repeat containing 41 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband
Chromosome location (bp)	46261196 - 46303608
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132128 (version 83.38)
Entrez gene	10489
UniProt	Q15345 (UniProt - Evidence at protein level)
neXtProt	NX_Q15345
Antibodypedia	LRRC41 antibodies

PROTEIN BROWSER

LRRC41-001	LRRC41-005	LRRC41-006	LRRC41-201	LRRC41-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC41-001 ENSP00000477792 ENST00000617190	Q15345 [Direct mapping] Leucine-rich repeat-containing protein 41 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0042803 [protein homodimerization activity] Show all	812 aa 88.6 kDa	No	0
LRRC41-005 ENSP00000477909 ENST00000496156	A0A087WTI9 [Direct mapping] Leucine-rich repeat-containing protein 41 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 25.2 kDa	No	0
LRRC41-006 ENSP00000484752 ENST00000615587	A0A0B4J2G4 [Direct mapping] Leucine-rich repeat-containing protein 41 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		790 aa 86.2 kDa	No	0
LRRC41-201 ENSP00000343298 ENST00000343304	Q15345 [Direct mapping] Leucine-rich repeat-containing protein 41 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016567 [protein ubiquitination] Show all	812 aa 88.6 kDa	No	0
LRRC41-202 ENSP00000484558 ENST00000617760	A0A0C4DH00 [Direct mapping] Leucine-rich repeat-containing protein 41 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		617 aa 67 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.