Fields »
ABOUT
HELP
BLOG
SLC6A11

GENERAL INFORMATION

Gene name

 SLC6A11

Gene description

 Solute carrier family 6 (neurotransmitter transporter), member 11

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (HaCaT, Hep G2, hTCEpi, NTERA-2)
HPA (normal tissue):Tissue enhanced (cerebral cortex, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA037981
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037981

GENE INFORMATION

Gene name

 SLC6A11 (HGNC Symbol)

Synonyms

 GAT3

Description

 Solute carrier family 6 (neurotransmitter transporter), member 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 10816200 - 10940733

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132164 (version 83.38)

Entrez gene

 6538

UniProt

 P48066 (UniProt - Evidence at transcript level)

neXtProt

 NX_P48066

Antibodypedia

 SLC6A11 antibodies

PROTEIN BROWSER
SLC6A11-001
SLC6A11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A11-001
ENSP00000254488
ENST00000254488
P48066 [Direct mapping]
Sodium- and chloride-dependent GABA transporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042165 [neurotransmitter binding]
GO:0042493 [response to drug]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
Show all
 632 aa
70.6 kDa 		No >9
SLC6A11-002
ENSP00000404120
ENST00000454147
P48066 [Direct mapping]
Sodium- and chloride-dependent GABA transporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016021 [integral component of membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
Show all
 208 aa
23 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.