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PPARG

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GENERAL INFORMATION

Gene name

 PPARG

Gene description

 Peroxisome proliferator-activated receptor gamma

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & vesicles.

RNA cell category

 Cell line enhanced (BEWO, RT4, PC-3, HDLM-2, CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated), Vesicles (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA051239 , HPA063663
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, RT4, PC-3, HDLM-2, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & vesicles.

Main location

 Nucleus (validated), Vesicles (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051239 PC-3 Nucleus
HPA051239 RT4 No staining    
HPA051239 U-2 OS Vesicles
HPA063663 PC-3 No staining    
HPA063663 RT4 Nucleus
HPA063663 U-2 OS Vesicles

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000000440 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA051239 NIH 3T3 No staining

GENE INFORMATION

Gene name

 PPARG (HGNC Symbol)

Synonyms

 NR1C3, PPARG1, PPARG2, PPARgamma

Description

 Peroxisome proliferator-activated receptor gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12287368 - 12434356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132170 (version 83.38)

Entrez gene

 5468

UniProt

 P37231 (UniProt - Evidence at protein level)

neXtProt

 NX_P37231

Antibodypedia

 PPARG antibodies

PROTEIN BROWSER
PPARG-001
PPARG-002
PPARG-003
PPARG-004
PPARG-005
PPARG-007
PPARG-009
PPARG-013
PPARG-015
PPARG-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPARG-001
ENSP00000380207
ENST00000397012
P37231 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
D2KUA6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor gamma; Peroxisome proliferative activated receptor gamma isoform 6 variant; Peroxisome proliferative activated receptor, gamma, isoform CRA_a; Peroxisome proliferator-activated nuclear receptor gamma variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004955 [prostaglandin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0015909 [long-chain fatty acid transport]
GO:0019899 [enzyme binding]
GO:0030224 [monocyte differentiation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030855 [epithelial cell differentiation]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033613 [activating transcription factor binding]
GO:0033993 [response to lipid]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042953 [lipoprotein transport]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045713 [low-density lipoprotein particle receptor biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048469 [cell maturation]
GO:0048511 [rhythmic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050544 [arachidonic acid binding]
GO:0050872 [white fat cell differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051393 [alpha-actinin binding]
GO:0055088 [lipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060694 [regulation of cholesterol transporter activity]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 477 aa
54.7 kDa 		No 0
PPARG-002
ENSP00000287820
ENST00000287820
P37231 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001890 [placenta development]
GO:0002021 [response to dietary excess]
GO:0002024 [diet induced thermogenesis]
GO:0002674 [negative regulation of acute inflammatory response]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004955 [prostaglandin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007507 [heart development]
GO:0007584 [response to nutrient]
GO:0008134 [transcription factor binding]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009409 [response to cold]
GO:0009612 [response to mechanical stimulus]
GO:0010033 [response to organic substance]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0014070 [response to organic cyclic compound]
GO:0015909 [long-chain fatty acid transport]
GO:0019216 [regulation of lipid metabolic process]
GO:0019395 [fatty acid oxidation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030224 [monocyte differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030331 [estrogen receptor binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030855 [epithelial cell differentiation]
GO:0031000 [response to caffeine]
GO:0031100 [organ regeneration]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0033613 [activating transcription factor binding]
GO:0033993 [response to lipid]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0036270 [response to diuretic]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0042594 [response to starvation]
GO:0042752 [regulation of circadian rhythm]
GO:0042953 [lipoprotein transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045444 [fat cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045713 [low-density lipoprotein particle receptor biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046321 [positive regulation of fatty acid oxidation]
GO:0046965 [retinoid X receptor binding]
GO:0048469 [cell maturation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048511 [rhythmic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050544 [arachidonic acid binding]
GO:0050872 [white fat cell differentiation]
GO:0050873 [brown fat cell differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051393 [alpha-actinin binding]
GO:0051974 [negative regulation of telomerase activity]
GO:0055088 [lipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060694 [regulation of cholesterol transporter activity]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0071285 [cellular response to lithium ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071306 [cellular response to vitamin E]
GO:0071379 [cellular response to prostaglandin stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071455 [cellular response to hyperoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1901558 [response to metformin]
GO:2000230 [negative regulation of pancreatic stellate cell proliferation]
Show all
 505 aa
57.6 kDa 		No 0
PPARG-003
ENSP00000380205
ENST00000397010
P37231 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
D2KUA6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor gamma; Peroxisome proliferative activated receptor gamma isoform 6 variant; Peroxisome proliferative activated receptor, gamma, isoform CRA_a; Peroxisome proliferator-activated nuclear receptor gamma variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004955 [prostaglandin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0015909 [long-chain fatty acid transport]
GO:0019899 [enzyme binding]
GO:0030224 [monocyte differentiation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030855 [epithelial cell differentiation]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033613 [activating transcription factor binding]
GO:0033993 [response to lipid]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042953 [lipoprotein transport]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045713 [low-density lipoprotein particle receptor biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048469 [cell maturation]
GO:0048511 [rhythmic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050544 [arachidonic acid binding]
GO:0050872 [white fat cell differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051393 [alpha-actinin binding]
GO:0055088 [lipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060694 [regulation of cholesterol transporter activity]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 477 aa
54.7 kDa 		No 0
PPARG-004
ENSP00000411931
ENST00000455517
E9PFJ1 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
Show all
 43 aa
4.9 kDa 		No 0
PPARG-005
ENSP00000380221
ENST00000397026
E9PFV2 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 483 aa
55.4 kDa 		No 0
PPARG-007
ENSP00000312472
ENST00000309576
P37231 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
D2KUA6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor gamma; Peroxisome proliferative activated receptor gamma isoform 6 variant; Peroxisome proliferative activated receptor, gamma, isoform CRA_a; Peroxisome proliferator-activated nuclear receptor gamma variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004955 [prostaglandin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0015909 [long-chain fatty acid transport]
GO:0019899 [enzyme binding]
GO:0030224 [monocyte differentiation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030855 [epithelial cell differentiation]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033613 [activating transcription factor binding]
GO:0033993 [response to lipid]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042953 [lipoprotein transport]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045713 [low-density lipoprotein particle receptor biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048469 [cell maturation]
GO:0048511 [rhythmic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050544 [arachidonic acid binding]
GO:0050872 [white fat cell differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051393 [alpha-actinin binding]
GO:0055088 [lipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060694 [regulation of cholesterol transporter activity]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 477 aa
54.7 kDa 		No 0
PPARG-009
ENSP00000380196
ENST00000397000
E9PFX5 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 250 aa
28.5 kDa 		No 0
PPARG-013
ENSP00000380210
ENST00000397015
P37231 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
D2KUA6 [Target identity:100%; Query identity:100%]
Peroxisome proliferative activated receptor gamma; Peroxisome proliferative activated receptor gamma isoform 6 variant; Peroxisome proliferative activated receptor, gamma, isoform CRA_a; Peroxisome proliferator-activated nuclear receptor gamma variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001890 [placenta development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004955 [prostaglandin receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0015909 [long-chain fatty acid transport]
GO:0019899 [enzyme binding]
GO:0030224 [monocyte differentiation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030855 [epithelial cell differentiation]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033613 [activating transcription factor binding]
GO:0033993 [response to lipid]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042953 [lipoprotein transport]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045713 [low-density lipoprotein particle receptor biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048469 [cell maturation]
GO:0048511 [rhythmic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050544 [arachidonic acid binding]
GO:0050872 [white fat cell differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051393 [alpha-actinin binding]
GO:0055088 [lipid homeostasis]
GO:0055098 [response to low-density lipoprotein particle]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0060694 [regulation of cholesterol transporter activity]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0090575 [RNA polymerase II transcription factor complex]
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 477 aa
54.7 kDa 		No 0
PPARG-015
ENSP00000380224
ENST00000397029
E7EUD1 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
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 132 aa
15 kDa 		No 0
PPARG-017
ENSP00000392285
ENST00000438682
E7EU07 [Direct mapping]
Peroxisome proliferator-activated receptor gamma
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030522 [intracellular receptor signaling pathway]
Show all
 99 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.