Expression of HSD17B7 in cancer - Summary - The Human Protein Atlas

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HSD17B7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HSD17B7
Gene description	Hydroxysteroid (17-beta) dehydrogenase 7
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA047496
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047496

GENE INFORMATION
Gene name	HSD17B7 (HGNC Symbol)
Synonyms	PRAP, SDR37C1
Description	Hydroxysteroid (17-beta) dehydrogenase 7 (HGNC Symbol)
Entrez gene summary	HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	162790702 - 162812817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132196 (version 83.38)
Entrez gene	51478
UniProt	P56937 (UniProt - Evidence at protein level)
neXtProt	NX_P56937
Antibodypedia	HSD17B7 antibodies

PROTEIN BROWSER

HSD17B7-001	HSD17B7-005	HSD17B7-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD17B7-001 ENSP00000254521 ENST00000254521	P56937 [Direct mapping] 3-keto-steroid reductase A0A024R913 [Target identity:100%; Query identity:100%] HCG2024989, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000253 [3-keto sterol reductase activity] GO:0004303 [estradiol 17-beta-dehydrogenase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006695 [cholesterol biosynthetic process] GO:0006703 [estrogen biosynthetic process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	341 aa 38.2 kDa	Yes	1
HSD17B7-005 ENSP00000356892 ENST00000367915	Q5T249 [Direct mapping] 3-keto-steroid reductase; HCG2024989, isoform CRA_g Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	84 aa 9.1 kDa	Yes	0
HSD17B7-007 ENSP00000356889 ENST00000367913	Q5T248 [Direct mapping] 3-keto-steroid reductase; HCG2024989, isoform CRA_e Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	111 aa 12.1 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.