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ARFIP2

GENERAL INFORMATION

Gene name

 ARFIP2

Gene description

 ADP-ribosylation factor interacting protein 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, most abundant in breast and prostate.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA038156 , CAB032985
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038156
CAB032985

GENE INFORMATION

Gene name

 ARFIP2 (HGNC Symbol)

Synonyms

 POR1

Description

 ADP-ribosylation factor interacting protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 6474683 - 6481479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132254 (version 83.38)

Entrez gene

 23647

UniProt

 P53365 (UniProt - Evidence at protein level)

neXtProt

 NX_P53365

Antibodypedia

 ARFIP2 antibodies

PROTEIN BROWSER
ARFIP2-001
ARFIP2-005
ARFIP2-008
ARFIP2-009
ARFIP2-010
ARFIP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFIP2-001
ENSP00000379998
ENST00000396777
P53365 [Direct mapping]
Arfaptin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0031529 [ruffle organization]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0048365 [Rac GTPase binding]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 341 aa
37.9 kDa 		No 0
ARFIP2-005
ENSP00000434124
ENST00000525235
E9PRV8 [Direct mapping]
Arfaptin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0019904 [protein domain specific binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
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 202 aa
21.7 kDa 		No 0
ARFIP2-008
ENSP00000254584
ENST00000254584
P53365 [Direct mapping]
Arfaptin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0031529 [ruffle organization]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0048365 [Rac GTPase binding]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 341 aa
37.9 kDa 		No 0
ARFIP2-009
ENSP00000391427
ENST00000445086
P53365 [Direct mapping]
Arfaptin-2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0031529 [ruffle organization]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0048365 [Rac GTPase binding]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 256 aa
29 kDa 		Yes 0
ARFIP2-010
ENSP00000398375
ENST00000423813
P53365 [Direct mapping]
Arfaptin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0031529 [ruffle organization]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0048365 [Rac GTPase binding]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 303 aa
33.8 kDa 		No 0
ARFIP2-201
ENSP00000484121
ENST00000614314
A0A087X1E4 [Direct mapping]
Arfaptin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0019904 [protein domain specific binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 374 aa
41.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.