Expression of IMMT in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	IMMT
Gene description	Inner membrane protein, mitochondrial
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in heart, stomach and the renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA036164 , HPA036165 , CAB022439
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036164	HPA036165	CAB022439

GENE INFORMATION
Gene name	IMMT (HGNC Symbol)
Synonyms	HMP, Mic60, MINOS2, P87, P89
Description	Inner membrane protein, mitochondrial (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	86143932 - 86195770
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132305 (version 83.38)
Entrez gene	10989
UniProt	Q16891 (UniProt - Evidence at protein level)
neXtProt	NX_Q16891
Antibodypedia	IMMT antibodies

PROTEIN BROWSER

IMMT-001	IMMT-002	IMMT-003	IMMT-005	IMMT-007	IMMT-014	IMMT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMMT-001 ENSP00000387262 ENST00000410111	Q16891 [Direct mapping] MICOS complex subunit MIC60 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0042407 [cristae formation] GO:0043209 [myelin sheath] GO:0044822 [poly(A) RNA binding] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0061617 [MICOS complex] Show all	758 aa 83.7 kDa	No	0
IMMT-002 ENSP00000396899 ENST00000449247	Q16891 [Direct mapping] MICOS complex subunit MIC60 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0042407 [cristae formation] GO:0044822 [poly(A) RNA binding] GO:0061617 [MICOS complex] Show all	747 aa 82.6 kDa	No	0
IMMT-003 ENSP00000387227 ENST00000409051	B9A067 [Direct mapping] MICOS complex subunit MIC60 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	711 aa 79 kDa	No	0
IMMT-005 ENSP00000254636 ENST00000254636	C9J406 [Direct mapping] MICOS complex subunit MIC60 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	659 aa 73.3 kDa	No	0
IMMT-007 ENSP00000415762 ENST00000419070	H7C463 [Direct mapping] MICOS complex subunit MIC60 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	613 aa 68.1 kDa	No	0
IMMT-014 ENSP00000407788 ENST00000442664	Q16891 [Direct mapping] MICOS complex subunit MIC60 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0042407 [cristae formation] GO:0044822 [poly(A) RNA binding] GO:0061617 [MICOS complex] Show all	757 aa 83.5 kDa	No	0
IMMT-201 ENSP00000482042 ENST00000620815	A0A087WYS0 [Direct mapping] MICOS complex subunit MIC60 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	372 aa 40.5 kDa	No	0