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SCLY

GENERAL INFORMATION

Gene name

 SCLY

Gene description

 Selenocysteine lyase

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA055760
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SCLY (HGNC Symbol)

Synonyms

 SCL

Description

 Selenocysteine lyase (HGNC Symbol)

Entrez gene summary

 Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 238060889 - 238099413

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132330 (version 83.38)

Entrez gene

 51540

UniProt

 Q96I15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96I15

Antibodypedia

 SCLY antibodies

PROTEIN BROWSER
SCLY-001
SCLY-003
SCLY-006
SCLY-008
SCLY-011
SCLY-013
SCLY-017
SCLY-019
SCLY-020
SCLY-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCLY-001
ENSP00000254663
ENST00000254663
A0A0A0MQU4 [Direct mapping]
Selenocysteine lyase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 453 aa
48.8 kDa 		No 0
SCLY-003
ENSP00000387162
ENST00000409736
Q96I15 [Direct mapping]
Selenocysteine lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0009000 [selenocysteine lyase activity]
GO:0016740 [transferase activity]
Show all
 317 aa
34 kDa 		No 0
SCLY-006
ENSP00000414053
ENST00000450965
H7C3V9 [Direct mapping]
Selenocysteine lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 241 aa
26.2 kDa 		No 0
SCLY-008
ENSP00000414165
ENST00000413463
C9JNL5 [Direct mapping]
Selenocysteine lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 171 aa
17.9 kDa 		No 0
SCLY-011
ENSP00000416344
ENST00000412508
H7C4A1 [Direct mapping]
Selenocysteine lyase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 196 aa
21.2 kDa 		No 0
SCLY-013
ENSP00000404473
ENST00000416757
H7C280 [Direct mapping]
Selenocysteine lyase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 151 aa
16.3 kDa 		No 0
SCLY-017
ENSP00000401401
ENST00000433750
H7C1N7 [Direct mapping]
Selenocysteine lyase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 122 aa
13.7 kDa 		No 0
SCLY-019
ENSP00000402078
ENST00000431487
H7C1S7 [Direct mapping]
Selenocysteine lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 168 aa
17.9 kDa 		No 0
SCLY-020
ENSP00000404444
ENST00000437134
H7C277 [Direct mapping]
Selenocysteine lyase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 251 aa
26.9 kDa 		No 1
SCLY-021
ENSP00000405907
ENST00000440143
H7C2H3 [Direct mapping]
Selenocysteine lyase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.