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RAN

GENERAL INFORMATION

Gene name

 RAN

Gene description

 RAN, member RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RAN (HGNC Symbol)

Synonyms

 ARA24, Gsp1, TC4

Description

 RAN, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 130871879 - 130877678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132341 (version 83.38)

Entrez gene

 5901

UniProt

 P62826 (UniProt - Evidence at protein level)

neXtProt

 NX_P62826

Antibodypedia

 RAN antibodies

PROTEIN BROWSER
RAN-001
RAN-003
RAN-004
RAN-005
RAN-008
RAN-010
RAN-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAN-001
ENSP00000446215
ENST00000543796
P62826 [Direct mapping]
GTP-binding nuclear protein Ran
Show all
Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000060 [protein import into nucleus, translocation]
GO:0000785 [chromatin]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006259 [DNA metabolic process]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019003 [GDP binding]
GO:0019058 [viral life cycle]
GO:0030036 [actin cytoskeleton organization]
GO:0030496 [midbody]
GO:0030521 [androgen receptor signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0032092 [positive regulation of protein binding]
GO:0034613 [cellular protein localization]
GO:0034629 [cellular protein complex localization]
GO:0035281 [pre-miRNA export from nucleus]
GO:0042470 [melanosome]
GO:0042565 [RNA nuclear export complex]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0051301 [cell division]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070883 [pre-miRNA binding]
GO:0075733 [intracellular transport of virus]
GO:1902570 [protein localization to nucleolus]
Show all
 216 aa
24.4 kDa 		No 0
RAN-003
ENSP00000376176
ENST00000392369
P62826 [Direct mapping]
GTP-binding nuclear protein Ran
Show all
Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000060 [protein import into nucleus, translocation]
GO:0000785 [chromatin]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006259 [DNA metabolic process]
GO:0006606 [protein import into nucleus]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019003 [GDP binding]
GO:0019058 [viral life cycle]
GO:0030496 [midbody]
GO:0030521 [androgen receptor signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0032092 [positive regulation of protein binding]
GO:0035281 [pre-miRNA export from nucleus]
GO:0042470 [melanosome]
GO:0042565 [RNA nuclear export complex]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0051301 [cell division]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070883 [pre-miRNA binding]
GO:0075733 [intracellular transport of virus]
GO:1902570 [protein localization to nucleolus]
Show all
 216 aa
24.4 kDa 		No 0
RAN-004
ENSP00000396127
ENST00000448750
J3KQE5 [Direct mapping]
GTP-binding nuclear protein Ran
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006606 [protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 234 aa
26.8 kDa 		No 0
RAN-005
ENSP00000376174
ENST00000392367
B5MDF5 [Direct mapping]
GTP-binding nuclear protein Ran; RAN, member RAS oncogene family, isoform CRA_c
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006606 [protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 233 aa
26.2 kDa 		No 0
RAN-008
ENSP00000441210
ENST00000541630
B4DV51 [Direct mapping]
GTP-binding nuclear protein Ran; cDNA FLJ52168, highly similar to GTP-binding nuclear protein Ran; cDNA, FLJ79092, highly similar to GTP-binding nuclear protein Ran
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006606 [protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
Show all
 128 aa
14.7 kDa 		No 0
RAN-010
ENSP00000444042
ENST00000535090
F5H018 [Direct mapping]
GTP-binding nuclear protein Ran
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006606 [protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 199 aa
22.5 kDa 		No 0
RAN-012
ENSP00000483687
ENST00000541679
A0A087X0W0 [Direct mapping]
GTP-binding nuclear protein Ran
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006606 [protein import into nucleus]
Show all
 53 aa
5.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.