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MYBBP1A

GENERAL INFORMATION

Gene name

 MYBBP1A

Gene description

 MYB binding protein (P160) 1a

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA005466
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), renal cancer (unfavourable), thyroid cancer (unfavourable) and melanoma (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Thyroid cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005466

GENE INFORMATION

Gene name

 MYBBP1A (HGNC Symbol)

Synonyms

 FLJ37886, P160, PAP2

Description

 MYB binding protein (P160) 1a (HGNC Symbol)

Entrez gene summary

 This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4538897 - 4555631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132382 (version 83.38)

Entrez gene

 10514

UniProt

 Q9BQG0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQG0

Antibodypedia

 MYBBP1A antibodies

PROTEIN BROWSER
MYBBP1A-001
MYBBP1A-002
MYBBP1A-009
MYBBP1A-011
MYBBP1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYBBP1A-001
ENSP00000254718
ENST00000254718
Q9BQG0 [Direct mapping]
Myb-binding protein 1A
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001047 [core promoter binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006913 [nucleocytoplasmic transport]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0032922 [circadian regulation of gene expression]
GO:0042149 [cellular response to glucose starvation]
GO:0042564 [NLS-dependent protein nuclear import complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071897 [DNA biosynthetic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000210 [positive regulation of anoikis]
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 1328 aa
148.9 kDa 		No 0
MYBBP1A-002
ENSP00000458919
ENST00000573116
I3L1L3 [Direct mapping]
Myb-binding protein 1A
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005488 [binding]
GO:0006351 [transcription, DNA-templated]
GO:0071897 [DNA biosynthetic process]
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 1252 aa
140.1 kDa 		No 0
MYBBP1A-009
ENSP00000459692
ENST00000573723
I3L2H8 [Direct mapping]
Myb-binding protein 1A
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0071897 [DNA biosynthetic process]
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 204 aa
22.7 kDa 		No 0
MYBBP1A-011
ENSP00000460087
ENST00000572759
I3L311 [Direct mapping]
Myb-binding protein 1A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 69 aa
7.3 kDa 		No 0
MYBBP1A-201
ENSP00000370968
ENST00000381556
Q9BQG0 [Direct mapping]
Myb-binding protein 1A
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001047 [core promoter binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006913 [nucleocytoplasmic transport]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0022904 [respiratory electron transport chain]
GO:0032922 [circadian regulation of gene expression]
GO:0042149 [cellular response to glucose starvation]
GO:0042564 [NLS-dependent protein nuclear import complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071897 [DNA biosynthetic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000210 [positive regulation of anoikis]
Show all
 1332 aa
149.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.