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Extracellular positivity and cytoplasmic expression in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Several cases of melanoma, gliomas, skin, breast and endometrial cancers showed moderate to strong cytoplasmic positivity. Other cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
SERPINF1 (HGNC Symbol)
Synonyms
EPC-1, PEDF, PIG35
Description
Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]