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EEFSEC

GENERAL INFORMATION

Gene name

 EEFSEC

Gene description

 Eukaryotic elongation factor, selenocysteine-tRNA-specific

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035795
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035795

GENE INFORMATION

Gene name

 EEFSEC (HGNC Symbol)

Synonyms

 EFSEC, SELB

Description

 Eukaryotic elongation factor, selenocysteine-tRNA-specific (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 128153454 - 128408646

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132394 (version 83.38)

Entrez gene

 60678

UniProt

 P57772 (UniProt - Evidence at protein level)

neXtProt

 NX_P57772

Antibodypedia

 EEFSEC antibodies

PROTEIN BROWSER
EEFSEC-001
EEFSEC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EEFSEC-001
ENSP00000254730
ENST00000254730
P57772 [Direct mapping]
Selenocysteine-specific elongation factor
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0001514 [selenocysteine incorporation]
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0030529 [ribonucleoprotein complex]
GO:0035368 [selenocysteine insertion sequence binding]
GO:0043021 [ribonucleoprotein complex binding]
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 596 aa
65.3 kDa 		No 0
EEFSEC-002
ENSP00000417660
ENST00000483457
C9J8T0 [Direct mapping]
Selenocysteine-specific elongation factor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 436 aa
47.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.