Expression of PNISR in cancer - Summary - The Human Protein Atlas

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PNISR

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNISR
Gene description	PNN-interacting serine/arginine-rich protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038796
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), renal cancer (unfavourable) and pancreatic cancer (favourable).
Urothelial cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038796

GENE INFORMATION
Gene name	PNISR (HGNC Symbol)
Synonyms	bA98I9.2, C6orf111, DKFZp564B0769, FLJ14752, SFRS18, SRrp130
Description	PNN-interacting serine/arginine-rich protein (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q16.2
Chromosome location (bp)	99398051 - 99425331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132424 (version 83.38)
Entrez gene	25957
UniProt	Q8TF01 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF01
Antibodypedia	PNISR antibodies

PROTEIN BROWSER

PNISR-007	PNISR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNISR-007 ENSP00000358242 ENST00000369239	Q8TF01 [Direct mapping] Arginine/serine-rich protein PNISR Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] Show all	805 aa 92.6 kDa	No	0
PNISR-201 ENSP00000387997 ENST00000438806	Q8TF01 [Direct mapping] Arginine/serine-rich protein PNISR Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] Show all	805 aa 92.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.