Expression of LANCL2 in cancer - Summary

GENERAL INFORMATION
Gene name	LANCL2
Gene description	LanC lantibiotic synthetase component C-like 2 (bacterial)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (A-431)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues, most abundant in smooth muscle and subsets of cells in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA019711 , HPA029535
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019711	HPA029535

GENE INFORMATION
Gene name	LANCL2 (HGNC Symbol)
Synonyms	GPR69B, TASP
Description	LanC lantibiotic synthetase component C-like 2 (bacterial) (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p11.2
Chromosome location (bp)	55365448 - 55433742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132434 (version 83.38)
Entrez gene	55915
UniProt	Q9NS86 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NS86
Antibodypedia	LANCL2 antibodies

PROTEIN BROWSER

LANCL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LANCL2-001 ENSP00000254770 ENST00000254770	Q9NS86 [Direct mapping] LanC-like protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0009789 [positive regulation of abscisic acid-activated signaling pathway] GO:0010314 [phosphatidylinositol-5-phosphate binding] GO:0030864 [cortical actin cytoskeleton] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	450 aa 50.9 kDa	No	0