Cell atlas - DDC - The Human Protein Atlas

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DDC

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	DDC
Gene description	Dopa decarboxylase (aromatic L-amino acid decarboxylase)
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the actin filaments.
RNA cell category	Group enriched (SCLC-21H, SH-SY5Y, CACO-2, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017742
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y, CACO-2, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the actin filaments.

Main location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017742	CACO-2	Actin filaments
	HPA017742	SH-SY5Y	Actin filaments
	HPA017742	U-2 OS	Actin filaments	Intensity

GENE INFORMATION
Gene name	DDC (HGNC Symbol)
Synonyms	AADC
Description	Dopa decarboxylase (aromatic L-amino acid decarboxylase) (HGNC Symbol)
Entrez gene summary	The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Chromosome	7
Cytoband
Chromosome location (bp)	50458436 - 50565457
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132437 (version 83.38)
Entrez gene	1644
UniProt	P20711 (UniProt - Evidence at protein level)
neXtProt	NX_P20711
Antibodypedia	DDC antibodies

PROTEIN BROWSER

DDC-001	DDC-002	DDC-003	DDC-006	DDC-009	DDC-013	DDC-014	DDC-201	DDC-202	DDC-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDC-001 ENSP00000350616 ENST00000357936	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0070062 [extracellular exosome] Show all	480 aa 53.9 kDa	No	0
DDC-002 ENSP00000403644 ENST00000444124	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0007623 [circadian rhythm] GO:0008021 [synaptic vesicle] GO:0009636 [response to toxic substance] GO:0010259 [multicellular organismal aging] GO:0015842 [synaptic vesicle amine transport] GO:0016597 [amino acid binding] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030170 [pyridoxal phosphate binding] GO:0030424 [axon] GO:0033076 [isoquinoline alkaloid metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035690 [cellular response to drug] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0042427 [serotonin biosynthetic process] GO:0043025 [neuronal cell body] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0046684 [response to pyrethroid] GO:0052314 [phytoalexin metabolic process] GO:0070062 [extracellular exosome] GO:0071312 [cellular response to alkaloid] GO:0071363 [cellular response to growth factor stimulus] Show all	480 aa 53.9 kDa	No	0
DDC-003 ENSP00000408626 ENST00000420203	C9JMP0 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.7 kDa	No	0
DDC-006 ENSP00000389422 ENST00000430300	H7BZF7 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	361 aa 40.9 kDa	No	0
DDC-009 ENSP00000399184 ENST00000431062	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0070062 [extracellular exosome] Show all	387 aa 44.2 kDa	No	0
DDC-013 ENSP00000395069 ENST00000426377	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0070062 [extracellular exosome] Show all	402 aa 45.5 kDa	No	0
DDC-014 ENSP00000370371 ENST00000380984	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0070062 [extracellular exosome] Show all	338 aa 37.1 kDa	No	0
DDC-201 ENSP00000484104 ENST00000615193	P20711 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004058 [aromatic-L-amino-acid decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0019899 [enzyme binding] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0036468 [L-dopa decarboxylase activity] GO:0042416 [dopamine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046219 [indolalkylamine biosynthetic process] GO:0070062 [extracellular exosome] Show all	387 aa 44.2 kDa	No	0
DDC-202 ENSP00000478385 ENST00000617822	A0A087WU57 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	432 aa 48.9 kDa	No	0
DDC-203 ENSP00000479110 ENST00000622873	A0A087WV24 [Direct mapping] Aromatic-L-amino-acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	442 aa 49.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.