Expression of JCHAIN in cancer - Summary

GENERAL INFORMATION
Gene name	JCHAIN
Gene description	Joining chain of multimeric IgA and IgM
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Daudi, Karpas-707, RPMI-8226, U-266/70, U-266/84, U-698)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in gastrointestinal tract and lymphoid tissues. Additional plasma positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA044132 , CAB034436
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), breast cancer (favourable) and renal cancer (unfavourable).
Head and neck cancer p<0.001 Breast cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA044132	CAB034436

GENE INFORMATION
Gene name	JCHAIN (HGNC Symbol)
Synonyms	IGCJ, IGJ, JCH
Description	Joining chain of multimeric IgA and IgM (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70655541 - 70681817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132465 (version 83.38)
Entrez gene	3512
UniProt	P01591 (UniProt - Evidence at protein level)
neXtProt	NX_P01591
Antibodypedia	JCHAIN antibodies

PROTEIN BROWSER

JCHAIN-001	JCHAIN-002	JCHAIN-004	JCHAIN-005	JCHAIN-006	JCHAIN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JCHAIN-001 ENSP00000254801 ENST00000254801	P01591 [Direct mapping] Immunoglobulin J chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0002250 [adaptive immune response] GO:0003094 [glomerular filtration] GO:0003697 [single-stranded DNA binding] GO:0003823 [antigen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0019731 [antibacterial humoral response] GO:0019862 [IgA binding] GO:0031210 [phosphatidylcholine binding] GO:0032461 [positive regulation of protein oligomerization] GO:0034987 [immunoglobulin receptor binding] GO:0042803 [protein homodimerization activity] GO:0042834 [peptidoglycan binding] GO:0045087 [innate immune response] GO:0060267 [positive regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071748 [monomeric IgA immunoglobulin complex] GO:0071750 [dimeric IgA immunoglobulin complex] GO:0071751 [secretory IgA immunoglobulin complex] GO:0071752 [secretory dimeric IgA immunoglobulin complex] GO:0071756 [pentameric IgM immunoglobulin complex] GO:0072562 [blood microparticle] Show all	159 aa 18.1 kDa	Yes	0
JCHAIN-002 ENSP00000417560 ENST00000470866	C9JA05 [Direct mapping] Protein JCHAIN Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8.2 kDa	Yes	0
JCHAIN-004 ENSP00000426045 ENST00000391614	D6RHJ6 [Direct mapping] Protein JCHAIN Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.7 kDa	Yes	0
JCHAIN-005 ENSP00000426687 ENST00000510437	P01591 [Direct mapping] Immunoglobulin J chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0002250 [adaptive immune response] GO:0003094 [glomerular filtration] GO:0003697 [single-stranded DNA binding] GO:0003823 [antigen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0019731 [antibacterial humoral response] GO:0019862 [IgA binding] GO:0031210 [phosphatidylcholine binding] GO:0032461 [positive regulation of protein oligomerization] GO:0034987 [immunoglobulin receptor binding] GO:0042803 [protein homodimerization activity] GO:0042834 [peptidoglycan binding] GO:0045087 [innate immune response] GO:0060267 [positive regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071748 [monomeric IgA immunoglobulin complex] GO:0071750 [dimeric IgA immunoglobulin complex] GO:0071751 [secretory IgA immunoglobulin complex] GO:0071752 [secretory dimeric IgA immunoglobulin complex] GO:0071756 [pentameric IgM immunoglobulin complex] GO:0072562 [blood microparticle] Show all	159 aa 18.1 kDa	Yes	0
JCHAIN-006 ENSP00000427112 ENST00000510614	D6RD17 [Direct mapping] Protein JCHAIN Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 18.1 kDa	Yes	0
JCHAIN-201 ENSP00000440066 ENST00000543780	P01591 [Direct mapping] Immunoglobulin J chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0002250 [adaptive immune response] GO:0003094 [glomerular filtration] GO:0003697 [single-stranded DNA binding] GO:0003823 [antigen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0019731 [antibacterial humoral response] GO:0019862 [IgA binding] GO:0031210 [phosphatidylcholine binding] GO:0032461 [positive regulation of protein oligomerization] GO:0034987 [immunoglobulin receptor binding] GO:0042803 [protein homodimerization activity] GO:0042834 [peptidoglycan binding] GO:0045087 [innate immune response] GO:0060267 [positive regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071748 [monomeric IgA immunoglobulin complex] GO:0071750 [dimeric IgA immunoglobulin complex] GO:0071751 [secretory IgA immunoglobulin complex] GO:0071752 [secretory dimeric IgA immunoglobulin complex] GO:0071756 [pentameric IgM immunoglobulin complex] GO:0072562 [blood microparticle] Show all	159 aa 18.1 kDa	Yes	0