Cell atlas - ANKRD17 - The Human Protein Atlas

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ANKRD17

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ANKRD17
Gene description	Ankyrin repeat domain 17
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nuclear membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA063731
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nuclear membrane.

Main location

Nucleus (supported)

Additional location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063731	CACO-2	Nucleoplasm
	HPA063731	RH-30	Nucleoplasm
	HPA063731	U-2 OS	Nucleus	Intensity
	HPA063731	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	ANKRD17 (HGNC Symbol)
Synonyms	FLJ22206, GTAR, KIAA0697, MASK2, NY-BR-16
Description	Ankyrin repeat domain 17 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73073376 - 73258798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132466 (version 83.38)
Entrez gene	26057
UniProt	O75179 (UniProt - Evidence at protein level)
neXtProt	NX_O75179
Antibodypedia	ANKRD17 antibodies

PROTEIN BROWSER

ANKRD17-001	ANKRD17-002	ANKRD17-003	ANKRD17-011	ANKRD17-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD17-001 ENSP00000351416 ENST00000358602	O75179 [Direct mapping] Ankyrin repeat domain-containing protein 17 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0001955 [blood vessel maturation] GO:0003676 [nucleic acid binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006275 [regulation of DNA replication] GO:0016020 [membrane] GO:0016032 [viral process] GO:0042742 [defense response to bacterium] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0045787 [positive regulation of cell cycle] GO:0051151 [negative regulation of smooth muscle cell differentiation] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900245 [positive regulation of MDA-5 signaling pathway] GO:1900246 [positive regulation of RIG-I signaling pathway] Show all	2603 aa 274.3 kDa	No	0
ANKRD17-002 ENSP00000332265 ENST00000330838	O75179 [Direct mapping] Ankyrin repeat domain-containing protein 17 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0003676 [nucleic acid binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006275 [regulation of DNA replication] GO:0016020 [membrane] GO:0016032 [viral process] GO:0042742 [defense response to bacterium] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0045787 [positive regulation of cell cycle] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900245 [positive regulation of MDA-5 signaling pathway] GO:1900246 [positive regulation of RIG-I signaling pathway] Show all	2352 aa 246.7 kDa	No	0
ANKRD17-003 ENSP00000427151 ENST00000509867	O75179 [Direct mapping] Ankyrin repeat domain-containing protein 17 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0003676 [nucleic acid binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006275 [regulation of DNA replication] GO:0016020 [membrane] GO:0016032 [viral process] GO:0042742 [defense response to bacterium] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0045787 [positive regulation of cell cycle] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900245 [positive regulation of MDA-5 signaling pathway] GO:1900246 [positive regulation of RIG-I signaling pathway] Show all	2490 aa 263.6 kDa	No	0
ANKRD17-011 ENSP00000453294 ENST00000561029	H0YLQ3 [Direct mapping] Ankyrin repeat domain-containing protein 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	862 aa 91.9 kDa	No	0
ANKRD17-012 ENSP00000453434 ENST00000558247	H0YM23 [Direct mapping] Ankyrin repeat domain-containing protein 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] Show all	2487 aa 263.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.