Expression of WBP2 in cancer - Summary - The Human Protein Atlas

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WBP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WBP2
Gene description	WW domain binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA065682
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065682

GENE INFORMATION
Gene name	WBP2 (HGNC Symbol)
Synonyms	WBP-2
Description	WW domain binding protein 2 (HGNC Symbol)
Entrez gene summary	The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75845699 - 75856507
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132471 (version 83.38)
Entrez gene	23558
UniProt	Q969T9 (UniProt - Evidence at protein level)
neXtProt	NX_Q969T9
Antibodypedia	WBP2 antibodies

PROTEIN BROWSER

WBP2-001	WBP2-003	WBP2-004	WBP2-008	WBP2-009	WBP2-010	WBP2-011	WBP2-018	WBP2-201	WBP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WBP2-001 ENSP00000467579 ENST00000591399	Q969T9 [Direct mapping] WW domain-binding protein 2 A0A024R8L1 [Target identity:100%; Query identity:100%] WW domain binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0005515 [protein binding] GO:0031490 [chromatin DNA binding] GO:0045184 [establishment of protein localization] GO:0045815 [positive regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071391 [cellular response to estrogen stimulus] GO:0071442 [positive regulation of histone H3-K14 acetylation] Show all	261 aa 28.1 kDa	No	0
WBP2-003 ENSP00000415251 ENST00000433525	B4DFG2 [Direct mapping] WW domain-binding protein 2; cDNA FLJ57063, highly similar to WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		216 aa 23.4 kDa	No	0
WBP2-004 ENSP00000467583 ENST00000585462	A6NG10 [Direct mapping] WW domain-binding protein 2; cDNA FLJ59459, highly similar to WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		239 aa 25.8 kDa	No	0
WBP2-008 ENSP00000466450 ENST00000590221	K7EMC9 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		257 aa 27.6 kDa	No	0
WBP2-009 ENSP00000464768 ENST00000593002	K7EIJ0 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 18.2 kDa	No	0
WBP2-010 ENSP00000468793 ENST00000589642	K7ESN4 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.1 kDa	No	0
WBP2-011 ENSP00000464820 ENST00000587374	K7EIN1 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12 kDa	No	0
WBP2-018 ENSP00000464782 ENST00000586257	K7EIK1 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		205 aa 21.5 kDa	No	0
WBP2-201 ENSP00000254806 ENST00000254806	Q969T9 [Direct mapping] WW domain-binding protein 2 A0A024R8L1 [Target identity:100%; Query identity:100%] WW domain binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0005515 [protein binding] GO:0031490 [chromatin DNA binding] GO:0045184 [establishment of protein localization] GO:0045815 [positive regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071391 [cellular response to estrogen stimulus] GO:0071442 [positive regulation of histone H3-K14 acetylation] Show all	261 aa 28.1 kDa	No	0
WBP2-202 ENSP00000486675 ENST00000626827	K7ENL2 [Direct mapping] WW domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		231 aa 24.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.