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H3F3B

GENERAL INFORMATION

Gene name

 H3F3B

Gene description

 H3 histone, family 3B (H3.3B)

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA042570 , CAB037166 , CAB037187 , CAB037221
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042570
CAB037166
CAB037187
CAB037221

GENE INFORMATION

Gene name

 H3F3B (HGNC Symbol)

Synonyms

 H3.3B

Description

 H3 histone, family 3B (H3.3B) (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75776434 - 75785893

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132475 (version 83.38)

Entrez gene

 3021

UniProt

 P84243 (UniProt - Evidence at protein level)

neXtProt

 NX_P84243

Antibodypedia

 H3F3B antibodies

PROTEIN BROWSER
H3F3B-001
H3F3B-003
H3F3B-005
H3F3B-006
H3F3B-007
H3F3B-009
H3F3B-010
H3F3B-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H3F3B-001
ENSP00000254810
ENST00000254810
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3B-003
ENSP00000466020
ENST00000586607
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3B-005
ENSP00000465813
ENST00000589599
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3B-006
ENSP00000465403
ENST00000586270
K7EK07 [Direct mapping]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 132 aa
14.9 kDa 		No 0
H3F3B-007
ENSP00000468714
ENST00000587560
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3B-009
ENSP00000468484
ENST00000587171
K7ES00 [Direct mapping]
Histone H3.3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 151 aa
16.6 kDa 		No 0
H3F3B-010
ENSP00000467165
ENST00000592643
K7EP01 [Direct mapping]
Histone H3.3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 113 aa
12.8 kDa 		No 0
H3F3B-011
ENSP00000466663
ENST00000591890
K7EMV3 [Direct mapping]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 92 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.