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EIF5A

GENERAL INFORMATION

Gene name

 EIF5A

Gene description

 Eukaryotic translation initiation factor 5A

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA061298 , CAB005042
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA061298
CAB005042

GENE INFORMATION

Gene name

 EIF5A (HGNC Symbol)

Synonyms

 EIF-5A, EIF5A1, MGC104255, MGC99547

Description

 Eukaryotic translation initiation factor 5A (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7306999 - 7312463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132507 (version 83.38)

Entrez gene

 1984

UniProt

 P63241 (UniProt - Evidence at protein level)

neXtProt

 NX_P63241

Antibodypedia

 EIF5A antibodies

PROTEIN BROWSER
EIF5A-001
EIF5A-002
EIF5A-004
EIF5A-005
EIF5A-006
EIF5A-007
EIF5A-009
EIF5A-010
EIF5A-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF5A-001
ENSP00000336776
ENST00000336458
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-002
ENSP00000336702
ENST00000336452
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 184 aa
20.2 kDa 		No 0
EIF5A-004
ENSP00000390677
ENST00000419711
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-005
ENSP00000458269
ENST00000571955
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-006
ENSP00000396073
ENST00000416016
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-007
ENSP00000459196
ENST00000576930
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-009
ENSP00000459611
ENST00000573542
P63241 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006452 [translational frameshifting]
GO:0006611 [protein export from nucleus]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008612 [peptidyl-lysine modification to peptidyl-hypusine]
GO:0016020 [membrane]
GO:0017070 [U6 snRNA binding]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.8 kDa 		No 0
EIF5A-010
ENSP00000460284
ENST00000573714
I3L397 [Direct mapping]
Eukaryotic translation initiation factor 5A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0006452 [translational frameshifting]
GO:0043022 [ribosome binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
Show all
 147 aa
16.1 kDa 		No 0
EIF5A-011
ENSP00000461688
ENST00000572815
I3L504 [Direct mapping]
Eukaryotic translation initiation factor 5A-1
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0006452 [translational frameshifting]
GO:0043022 [ribosome binding]
GO:0045901 [positive regulation of translational elongation]
GO:0045905 [positive regulation of translational termination]
Show all
 186 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.