Expression of SLC52A1 in cancer - Summary - The Human Protein Atlas

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SLC52A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC52A1
Gene description	Solute carrier family 52 (riboflavin transporter), member 1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, HMC-1, SK-BR-3)
HPA (normal tissue):	Group enriched (duodenum, placenta, skin, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending retesting.
Reliability score	Uncertain based on 1 antibody. CAB011449
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB011449

GENE INFORMATION
Gene name	SLC52A1 (HGNC Symbol)
Synonyms	FLJ10060, GPCR42, GPR172B, hRFT1, PAR2, RFVT1
Description	Solute carrier family 52 (riboflavin transporter), member 1 (HGNC Symbol)
Entrez gene summary	Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5032600 - 5052009
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132517 (version 83.38)
Entrez gene	55065
UniProt	Q9NWF4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWF4
Antibodypedia	SLC52A1 antibodies

PROTEIN BROWSER

SLC52A1-001	SLC52A1-002	SLC52A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC52A1-001 ENSP00000254853 ENST00000254853	Q9NWF4 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001618 [virus receptor activity] GO:0005887 [integral component of plasma membrane] GO:0032217 [riboflavin transporter activity] GO:0032218 [riboflavin transport] GO:0046718 [viral entry into host cell] Show all	448 aa 46.3 kDa	Yes	>9
SLC52A1-002 ENSP00000443026 ENST00000512825	F5H5Y1 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	350 aa 36.5 kDa	Yes	7
SLC52A1-201 ENSP00000399979 ENST00000424747	Q9NWF4 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001618 [virus receptor activity] GO:0005887 [integral component of plasma membrane] GO:0032217 [riboflavin transporter activity] GO:0032218 [riboflavin transport] GO:0046718 [viral entry into host cell] Show all	448 aa 46.3 kDa	Yes	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.