Fields »
ABOUT
HELP
BLOG
GUCY2D

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 GUCY2D

Gene description

 Guanylate cyclase 2D, membrane (retina-specific)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GUCY2D (HGNC Symbol)

Synonyms

 CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, retGC, RETGC-1, ROS-GC1

Description

 Guanylate cyclase 2D, membrane (retina-specific) (HGNC Symbol)

Entrez gene summary

 This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8002594 - 8020339

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132518 (version 83.38)

Entrez gene

 3000

UniProt

 Q02846 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02846

Antibodypedia

 GUCY2D antibodies

PROTEIN BROWSER
GUCY2D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCY2D-001
ENSP00000254854
ENST00000254854
Q02846 [Direct mapping]
Retinal guanylyl cyclase 1
Show all
Enzymes
   ENZYME proteins
   Lyases
   Kinases
   RGC receptor guanylate cyclase kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004672 [protein kinase activity]
GO:0004872 [receptor activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005640 [nuclear outer membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0097381 [photoreceptor disc membrane]
Show all
 1103 aa
120.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.