Cell atlas - GPS2 - The Human Protein Atlas

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GPS2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GPS2
Gene description	G protein pathway suppressor 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067540
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067540	CACO-2	Nucleoplasm
	HPA067540	HEK 293	Nucleoplasm
	HPA067540	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	GPS2
Synonyms
Description	G protein pathway suppressor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7311324 - 7315564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132522 (version 83.38)
Entrez gene	2874
UniProt	Q13227 (UniProt - Evidence at protein level)
neXtProt	NX_Q13227
Antibodypedia	GPS2 antibodies

PROTEIN BROWSER

GPS2-001	GPS2-004	GPS2-006	GPS2-012	GPS2-013	GPS2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPS2-001 ENSP00000370104 ENST00000380728	Q13227 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000188 [inactivation of MAPK activity] GO:0003714 [transcription corepressor activity] GO:0005095 [GTPase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0007049 [cell cycle] GO:0007254 [JNK cascade] GO:0017053 [transcriptional repressor complex] GO:0034260 [negative regulation of GTPase activity] GO:0046329 [negative regulation of JNK cascade] Show all	327 aa 36.7 kDa	No	0
GPS2-004 ENSP00000379841 ENST00000389167	Q13227 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000188 [inactivation of MAPK activity] GO:0003714 [transcription corepressor activity] GO:0005095 [GTPase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0007049 [cell cycle] GO:0007254 [JNK cascade] GO:0017053 [transcriptional repressor complex] GO:0034260 [negative regulation of GTPase activity] GO:0046329 [negative regulation of JNK cascade] Show all	327 aa 36.7 kDa	No	0
GPS2-006 ENSP00000460836 ENST00000570780	I3L3Y9 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		327 aa 36.3 kDa	No	0
GPS2-012 ENSP00000459357 ENST00000574458	I3L242 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8 kDa	No	0
GPS2-013 ENSP00000458837 ENST00000573684	I3L1H4 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		158 aa 16.8 kDa	No	0
GPS2-014 ENSP00000461624 ENST00000577040	I3L4X7 [Direct mapping] G protein pathway suppressor 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		259 aa 29.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.