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DLG4

GENERAL INFORMATION

Gene name

 DLG4

Gene description

 Discs, large homolog 4 (Drosophila)

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in CNS, including cerebellar basket cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA010122 , CAB001999 , CAB002000
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA010122
CAB001999
CAB002000

GENE INFORMATION

Gene name

 DLG4 (HGNC Symbol)

Synonyms

 PSD-95, PSD95, SAP-90, SAP90

Description

 Discs, large homolog 4 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7189890 - 7219702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132535 (version 83.38)

Entrez gene

 1742

UniProt

 P78352 (UniProt - Evidence at protein level)

neXtProt

 NX_P78352

Antibodypedia

 DLG4 antibodies

PROTEIN BROWSER
DLG4-001
DLG4-002
DLG4-003
DLG4-004
DLG4-006
DLG4-007
DLG4-008
DLG4-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLG4-001
ENSP00000382428
ENST00000399510
P78352 [Direct mapping]
Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002091 [negative regulation of receptor internalization]
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032403 [protein complex binding]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0035641 [locomotory exploration behavior]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044300 [cerebellar mossy fiber]
GO:0044306 [neuron projection terminus]
GO:0044309 [neuron spine]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050806 [positive regulation of synaptic transmission]
GO:0050885 [neuromuscular process controlling balance]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0071625 [vocalization behavior]
GO:0071944 [cell periphery]
GO:0097060 [synaptic membrane]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000821 [regulation of grooming behavior]
Show all
 767 aa
85.4 kDa 		Yes 0
DLG4-002
ENSP00000382425
ENST00000399506
P78352 [Direct mapping]
Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002091 [negative regulation of receptor internalization]
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014069 [postsynaptic density]
GO:0016188 [synaptic vesicle maturation]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032403 [protein complex binding]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044306 [neuron projection terminus]
GO:0044309 [neuron spine]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050806 [positive regulation of synaptic transmission]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 724 aa
80.5 kDa 		No 0
DLG4-003
ENSP00000307471
ENST00000302955
P78352 [Direct mapping]
Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002091 [negative regulation of receptor internalization]
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014069 [postsynaptic density]
GO:0016188 [synaptic vesicle maturation]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032403 [protein complex binding]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044306 [neuron projection terminus]
GO:0044309 [neuron spine]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050806 [positive regulation of synaptic transmission]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 721 aa
80.1 kDa 		No 0
DLG4-004
ENSP00000460625
ENST00000485100
O14909 [Direct mapping]
Discs, large homolog 4 (Drosophila), isoform CRA_d; Disks large homolog 4; Tax interaction protein 15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 296 aa
31.9 kDa 		No 0
DLG4-006
ENSP00000407918
ENST00000451807
C9JYG3 [Direct mapping]
Disks large homolog 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 281 aa
30.1 kDa 		No 0
DLG4-007
ENSP00000388122
ENST00000447163
C9JWP9 [Direct mapping]
Disks large homolog 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 234 aa
25 kDa 		No 0
DLG4-008
ENSP00000465789
ENST00000493294
K7EKU8 [Direct mapping]
Disks large homolog 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 91 aa
9.8 kDa 		No 0
DLG4-009
ENSP00000465720
ENST00000486626
K7EKP9 [Direct mapping]
Disks large homolog 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 116 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.