Expression of HRSP12 in cancer - Summary

GENERAL INFORMATION
Gene name	HRSP12
Gene description	Heat-responsive protein 12
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in a few cell types, most abundant in hepatocytes and proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA022856 , HPA023489
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA022856	HPA023489

GENE INFORMATION
Gene name	HRSP12 (HGNC Symbol)
Synonyms	P14.5, PSP, UK114
Description	Heat-responsive protein 12 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q22.2
Chromosome location (bp)	98102344 - 98117241
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132541 (version 83.38)
Entrez gene	10247
UniProt	P52758 (UniProt - Evidence at protein level)
neXtProt	NX_P52758
Antibodypedia	HRSP12 antibodies

PROTEIN BROWSER

HRSP12-001	HRSP12-003	HRSP12-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRSP12-001 ENSP00000254878 ENST00000254878	P52758 [Direct mapping] Ribonuclease UK114 A0A024R9H2 [Target identity:100%; Query identity:100%] Heat-responsive protein 12, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0006449 [regulation of translational termination] GO:0007420 [brain development] GO:0016892 [endoribonuclease activity, producing 3'-phosphomonoesters] GO:0017148 [negative regulation of translation] GO:0019239 [deaminase activity] GO:0030324 [lung development] GO:0033993 [response to lipid] GO:0036041 [long-chain fatty acid binding] GO:0042803 [protein homodimerization activity] GO:0043167 [ion binding] GO:0044822 [poly(A) RNA binding] GO:0046914 [transition metal ion binding] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0070062 [extracellular exosome] GO:0070314 [G1 to G0 transition] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1902074 [response to salt] GO:1904012 [platinum binding] GO:1904013 [xenon atom binding] Show all	137 aa 14.5 kDa	No	0
HRSP12-003 ENSP00000430482 ENST00000521560	H0YBX3 [Direct mapping] Ribonuclease UK114 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019239 [deaminase activity] Show all	127 aa 13.7 kDa	Yes	0
HRSP12-007 ENSP00000428596 ENST00000520507	H0YB34 [Direct mapping] Ribonuclease UK114 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0019239 [deaminase activity] Show all	148 aa 15.9 kDa	No	0