Expression of MATN2 in cancer - Summary - The Human Protein Atlas

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MATN2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MATN2
Gene description	Matrilin 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HaCaT, HBF TERT88)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. CAB033879
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB033879

GENE INFORMATION
Gene name	MATN2
Synonyms
Description	Matrilin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband
Chromosome location (bp)	97868840 - 98036716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132561 (version 83.38)
Entrez gene	4147
UniProt	O00339 (UniProt - Evidence at protein level)
neXtProt	NX_O00339
Antibodypedia	MATN2 antibodies

PROTEIN BROWSER

MATN2-001	MATN2-002	MATN2-004	MATN2-005	MATN2-006	MATN2-009	MATN2-010	MATN2-012	MATN2-013	MATN2-016	MATN2-017	MATN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MATN2-001 ENSP00000429977 ENST00000521689	O00339 [Direct mapping] Matrilin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008150 [biological_process] GO:0031012 [extracellular matrix] Show all	937 aa 104.8 kDa	Yes	0
MATN2-002 ENSP00000430221 ENST00000524308	O00339 [Direct mapping] Matrilin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008150 [biological_process] GO:0031012 [extracellular matrix] Show all	915 aa 102.2 kDa	Yes	0
MATN2-004 ENSP00000430487 ENST00000520016	O00339 [Direct mapping] Matrilin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008150 [biological_process] GO:0031012 [extracellular matrix] Show all	956 aa 106.8 kDa	Yes	0
MATN2-005 ENSP00000429010 ENST00000522025	O00339 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008150 [biological_process] GO:0031012 [extracellular matrix] Show all	672 aa 75.3 kDa	No	0
MATN2-006 ENSP00000429622 ENST00000518154	H0YBJ4 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	720 aa 80.5 kDa	No	0
MATN2-009 ENSP00000430396 ENST00000521041	H0YBV5 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	181 aa 20.1 kDa	No	0
MATN2-010 ENSP00000429042 ENST00000519585	E5RJM4 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	115 aa 12.7 kDa	No	0
MATN2-012 ENSP00000429825 ENST00000522270	H0YBM3 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	195 aa 21.8 kDa	No	0
MATN2-013 ENSP00000429885 ENST00000517321	H0YBN2 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	183 aa 20.2 kDa	No	0
MATN2-016 ENSP00000430358 ENST00000519582	H0YBU5 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 19.4 kDa	No	0
MATN2-017 ENSP00000429354 ENST00000522135	H0YBF2 [Direct mapping] Matrilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 15.1 kDa	No	0
MATN2-201 ENSP00000254898 ENST00000254898	O00339 [Direct mapping] Matrilin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003674 [molecular_function] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007411 [axon guidance] GO:0008150 [biological_process] GO:0008347 [glial cell migration] GO:0031012 [extracellular matrix] GO:0031104 [dendrite regeneration] GO:0031175 [neuron projection development] GO:0048678 [response to axon injury] Show all	956 aa 106.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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