Expression of REEP2 in cancer - Summary - The Human Protein Atlas

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REEP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	REEP2
Gene description	Receptor accessory protein 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AN3-CA, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in Purkinje cells and neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA031813
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable), glioma (unfavourable) and melanoma (favourable).
Breast cancer p<0.001 Glioma p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031813

GENE INFORMATION
Gene name	REEP2 (HGNC Symbol)
Synonyms	C5orf19, SGC32445, SPG72
Description	Receptor accessory protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	5
Cytoband	q31.2
Chromosome location (bp)	138439017 - 138446969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132563 (version 83.38)
Entrez gene	51308
UniProt	Q9BRK0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRK0
Antibodypedia	REEP2 antibodies

PROTEIN BROWSER

REEP2-001	REEP2-002	REEP2-003	REEP2-004	REEP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REEP2-001 ENSP00000367590 ENST00000378339	Q9BRK0 [Direct mapping] Receptor expression-enhancing protein 2 A8K3D2 [Target identity:100%; Query identity:100%] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005881 [cytoplasmic microtubule] GO:0005887 [integral component of plasma membrane] GO:0016021 [integral component of membrane] GO:0031883 [taste receptor binding] GO:0032386 [regulation of intracellular transport] GO:0032596 [protein transport into membrane raft] GO:0050913 [sensory perception of bitter taste] GO:0050916 [sensory perception of sweet taste] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	254 aa 28.4 kDa	No	2
REEP2-002 ENSP00000254901 ENST00000254901	Q9BRK0 [Direct mapping] Receptor expression-enhancing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005783 [endoplasmic reticulum] GO:0005881 [cytoplasmic microtubule] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	252 aa 28.3 kDa	No	2
REEP2-003 ENSP00000422530 ENST00000506158	B4DE60 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016020 [membrane] Show all	214 aa 23.8 kDa	No	1
REEP2-004 ENSP00000426658 ENST00000512126	H0YAC5 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	191 aa 21.9 kDa	No	2
REEP2-201 ENSP00000479268 ENST00000613650	A0A087WV88 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	151 aa 17.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.