Expression of NIP7 in cancer - Summary - The Human Protein Atlas

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NIP7

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NIP7
Gene description	NIP7, nucleolar pre-rRNA processing protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA059850
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059850

GENE INFORMATION
Gene name	NIP7 (HGNC Symbol)
Synonyms	CGI-37, FLJ10296, HSPC031, KD93
Description	NIP7, nucleolar pre-rRNA processing protein (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	69339430 - 69343111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132603 (version 83.38)
Entrez gene	51388
UniProt	Q9Y221 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y221
Antibodypedia	NIP7 antibodies

PROTEIN BROWSER

NIP7-001	NIP7-002	NIP7-004	NIP7-005	NIP7-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NIP7-001 ENSP00000254940 ENST00000254940	Q9Y221 [Direct mapping] 60S ribosome subunit biogenesis protein NIP7 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0042255 [ribosome assembly] GO:0044822 [poly(A) RNA binding] Show all	180 aa 20.5 kDa	No	0
NIP7-002 ENSP00000254941 ENST00000254941	Q9Y221 [Direct mapping] 60S ribosome subunit biogenesis protein NIP7 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0042255 [ribosome assembly] GO:0044822 [poly(A) RNA binding] Show all	133 aa 15.2 kDa	No	0
NIP7-004 ENSP00000464348 ENST00000567202	J3QRR4 [Direct mapping] 60S ribosome subunit biogenesis protein NIP7 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	79 aa 8.9 kDa	No	0
NIP7-005 ENSP00000464159 ENST00000562523	J3QRD6 [Direct mapping] 60S ribosome subunit biogenesis protein NIP7 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8 kDa	No	0
NIP7-007 ENSP00000463739 ENST00000569637	J3QLW7 [Direct mapping] 60S ribosome subunit biogenesis protein NIP7 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.