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TERF2

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GENERAL INFORMATION

Gene name

 TERF2

Gene description

 Telomeric repeat binding factor 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA001907
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear bodies.

Main location

 Nuclear bodies (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001907 U-2 OS Nuclear bodies

siRNA VALIDATION

Antibody

 HPA001907

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 72%53%

p-value

 < 0.01< 0.01
 

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Sample

Cell line
HPA001907 siRNA 2 U-2 OS
HPA001907 scrambled U-2 OS
HPA001907 siRNA 1 U-2 OS

GENE INFORMATION

Gene name

 TERF2 (HGNC Symbol)

Synonyms

 TRBF2, TRF2

Description

 Telomeric repeat binding factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 69355561 - 69408571

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132604 (version 83.38)

Entrez gene

 7014

UniProt

 Q15554 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15554

Antibodypedia

 TERF2 antibodies

PROTEIN BROWSER
TERF2-001
TERF2-002
TERF2-003
TERF2-006
TERF2-008
TERF2-011
TERF2-012
TERF2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TERF2-001
ENSP00000254942
ENST00000254942
Q15554 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001673 [male germ cell nucleus]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007004 [telomere maintenance via telomerase]
GO:0007049 [cell cycle]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016233 [telomere capping]
GO:0030870 [Mre11 complex]
GO:0031627 [telomeric loop formation]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032204 [regulation of telomere maintenance]
GO:0032205 [negative regulation of telomere maintenance]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032214 [negative regulation of telomere maintenance via semi-conservative replication]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
GO:0090344 [negative regulation of cell aging]
GO:0090398 [cellular senescence]
GO:1903770 [negative regulation of beta-galactosidase activity]
GO:1903824 [negative regulation of telomere single strand break repair]
GO:2000773 [negative regulation of cellular senescence]
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 542 aa
59.6 kDa 		No 0
TERF2-002
ENSP00000454955
ENST00000567296
Q15554 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007004 [telomere maintenance via telomerase]
GO:0007049 [cell cycle]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016233 [telomere capping]
GO:0030870 [Mre11 complex]
GO:0031627 [telomeric loop formation]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032204 [regulation of telomere maintenance]
GO:0032205 [negative regulation of telomere maintenance]
GO:0032214 [negative regulation of telomere maintenance via semi-conservative replication]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
GO:0090344 [negative regulation of cell aging]
GO:0090398 [cellular senescence]
GO:1903770 [negative regulation of beta-galactosidase activity]
GO:1903824 [negative regulation of telomere single strand break repair]
GO:2000773 [negative regulation of cellular senescence]
Show all
 293 aa
32.3 kDa 		No 0
TERF2-003
ENSP00000476905
ENST00000567841
V9GYM1 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 86 aa
9.7 kDa 		No 0
TERF2-006
ENSP00000456022
ENST00000566750
H3BR06 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 283 aa
31.5 kDa 		No 0
TERF2-008
ENSP00000463079
ENST00000566051
J3KTN8 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
Show all
 49 aa
5.7 kDa 		No 0
TERF2-011
ENSP00000475507
ENST00000569584
U3KQ35 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 244 aa
26.7 kDa 		No 0
TERF2-012
ENSP00000462726
ENST00000569542
J3KSZ6 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0042803 [protein homodimerization activity]
Show all
 144 aa
15.4 kDa 		No 0
TERF2-013
ENSP00000457094
ENST00000566257
H3BTA7 [Direct mapping]
Telomeric repeat-binding factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 206 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.