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SNAP25

GENERAL INFORMATION

Gene name

 SNAP25

Gene description

 Synaptosomal-associated protein, 25kDa

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, pancreatic cancer)
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001830 , CAB000360
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001830
CAB000360

GENE INFORMATION

Gene name

 SNAP25 (HGNC Symbol)

Synonyms

 bA416N4.2, dJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25

Description

 Synaptosomal-associated protein, 25kDa (HGNC Symbol)

Entrez gene summary

 Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.2

Chromosome location (bp)

 10218830 - 10307418

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132639 (version 83.38)

Entrez gene

 6616

UniProt

 P60880 (UniProt - Evidence at protein level)

neXtProt

 NX_P60880

Antibodypedia

 SNAP25 antibodies

PROTEIN BROWSER
SNAP25-002
SNAP25-003
SNAP25-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNAP25-002
ENSP00000400720
ENST00000430336
A0A0A0MSS0 [Direct mapping]
Synaptosomal-associated protein 25
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
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 93 aa
10.7 kDa 		No 0
SNAP25-003
ENSP00000254976
ENST00000254976
P60880 [Direct mapping]
Synaptosomal-associated protein 25
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001504 [neurotransmitter uptake]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007626 [locomotory behavior]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008306 [associative learning]
GO:0010975 [regulation of neuron projection development]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016081 [synaptic vesicle docking]
GO:0016082 [synaptic vesicle priming]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0031083 [BLOC-1 complex]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0031982 [vesicle]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
GO:0070201 [regulation of establishment of protein localization]
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 206 aa
23.3 kDa 		No 0
SNAP25-004
ENSP00000307341
ENST00000304886
P60880 [Direct mapping]
Synaptosomal-associated protein 25
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001504 [neurotransmitter uptake]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016081 [synaptic vesicle docking]
GO:0016082 [synaptic vesicle priming]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0031083 [BLOC-1 complex]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0031982 [vesicle]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
Show all
 206 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.