Expression of DCAF8 in cancer - Summary - The Human Protein Atlas

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DCAF8

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCAF8
Gene description	DDB1 and CUL4 associated factor 8
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA027218 , HPA027381
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027218	HPA027381

GENE INFORMATION
Gene name	DCAF8 (HGNC Symbol)
Synonyms	FLJ35857, H326, WDR42A
Description	DDB1 and CUL4 associated factor 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	160215715 - 160262531
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132716 (version 83.38)
Entrez gene	50717
UniProt	Q5TAQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TAQ9
Antibodypedia	DCAF8 antibodies

PROTEIN BROWSER

DCAF8-001	DCAF8-002	DCAF8-003	DCAF8-005	DCAF8-006	DCAF8-007	DCAF8-008	DCAF8-009	DCAF8-010	DCAF8-016	DCAF8-017	DCAF8-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCAF8-001 ENSP00000357052 ENST00000368073	Q5TAQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	597 aa 66.9 kDa	No	0
DCAF8-002 ENSP00000357053 ENST00000368074	Q5TAQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	597 aa 66.9 kDa	No	0
DCAF8-003 ENSP00000318227 ENST00000326837	Q5TAQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	597 aa 66.9 kDa	No	0
DCAF8-005 ENSP00000476351 ENST00000475733	Q5TAQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	273 aa 30.6 kDa	No	0
DCAF8-006 ENSP00000411875 ENST00000440682	Q5TAQ5 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		109 aa 11.6 kDa	No	0
DCAF8-007 ENSP00000413688 ENST00000447377	Q5TAQ8 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		212 aa 23.5 kDa	No	0
DCAF8-008 ENSP00000384118 ENST00000407642	Q5TAQ7 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		106 aa 11.2 kDa	No	0
DCAF8-009 ENSP00000409434 ENST00000419626	Q5TAQ6 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		41 aa 4.1 kDa	No	0
DCAF8-010 ENSP00000477012 ENST00000495887	V9GYQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		125 aa 14 kDa	No	0
DCAF8-016 ENSP00000477386 ENST00000477163	V9GZ39 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	66 aa 7.3 kDa	No	0
DCAF8-017 ENSP00000476539 ENST00000473382	V9GY98 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Show all		81 aa 9.5 kDa	No	0
DCAF8-018 ENSP00000477464 ENST00000610139	Q5TAQ9 [Direct mapping] DDB1- and CUL4-associated factor 8 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	273 aa 30.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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