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SYT11

GENERAL INFORMATION

Gene name

 SYT11

Gene description

 Synaptotagmin XI

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (Karpas-707, SCLC-21H, SH-SY5Y, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in CNS and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA064091
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA064091

GENE INFORMATION

Gene name

 SYT11 (HGNC Symbol)

Synonyms

 DKFZp781D015, KIAA0080, MGC10881, MGC17226

Description

 Synaptotagmin XI (HGNC Symbol)

Entrez gene summary

 This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155859509 - 155885199

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132718 (version 83.38)

Entrez gene

 23208

UniProt

 Q9BT88 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BT88

Antibodypedia

 SYT11 antibodies

PROTEIN BROWSER
SYT11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYT11-001
ENSP00000357307
ENST00000368324
Q9BT88 [Direct mapping]
Synaptotagmin-11
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008021 [synaptic vesicle]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0046929 [negative regulation of neurotransmitter secretion]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
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 431 aa
48.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.