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CTNNBL1

GENERAL INFORMATION

Gene name

 CTNNBL1

Gene description

 Catenin, beta like 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027907
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027907

GENE INFORMATION

Gene name

 CTNNBL1 (HGNC Symbol)

Synonyms

 C20orf33, FLJ21108, NAP, NYD-SP19, P14, P14L

Description

 Catenin, beta like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 37693955 - 37872129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132792 (version 83.38)

Entrez gene

 56259

UniProt

 Q8WYA6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYA6

Antibodypedia

 CTNNBL1 antibodies

PROTEIN BROWSER
CTNNBL1-001
CTNNBL1-002
CTNNBL1-004
CTNNBL1-007
CTNNBL1-008
CTNNBL1-201
CTNNBL1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNNBL1-001
ENSP00000355050
ENST00000361383
Q8WYA6 [Direct mapping]
Beta-catenin-like protein 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
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 563 aa
65.2 kDa 		No 0
CTNNBL1-002
ENSP00000362572
ENST00000373473
Q8WYA6 [Direct mapping]
Beta-catenin-like protein 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 376 aa
43.4 kDa 		No 0
CTNNBL1-004
ENSP00000362568
ENST00000373469
Q8WYA6 [Direct mapping]
Beta-catenin-like protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
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 311 aa
36.1 kDa 		No 0
CTNNBL1-007
ENSP00000394464
ENST00000447935
A2A2P1 [Direct mapping]
Beta-catenin-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 166 aa
19.2 kDa 		No 0
CTNNBL1-008
ENSP00000487198
ENST00000628103
Q8WYA6 [Direct mapping]
Beta-catenin-like protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 536 aa
62 kDa 		No 0
CTNNBL1-201
ENSP00000384355
ENST00000405275
Q8WYA6 [Direct mapping]
Beta-catenin-like protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 536 aa
62 kDa 		No 0
CTNNBL1-202
ENSP00000478532
ENST00000621317
A0A087WUB9 [Direct mapping]
Beta-catenin-like protein 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
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 568 aa
65.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.