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LPIN3

GENERAL INFORMATION

Gene name

 LPIN3

Gene description

 Lipin 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues including the gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA052667
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA052667

GENE INFORMATION

Gene name

 LPIN3 (HGNC Symbol)

Synonyms

 LIPN3L, SMP2

Description

 Lipin 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

 20

Cytoband

 q12

Chromosome location (bp)

 41340920 - 41360582

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132793 (version 83.38)

Entrez gene

 64900

UniProt

 Q9BQK8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQK8

Antibodypedia

 LPIN3 antibodies

PROTEIN BROWSER
LPIN3-001
LPIN3-003
LPIN3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPIN3-001
ENSP00000362354
ENST00000373257
Q9BQK8 [Direct mapping]
Phosphatidate phosphatase LPIN3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
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 851 aa
93.6 kDa 		No 0
LPIN3-003
ENSP00000398092
ENST00000445975
H0Y5E1 [Direct mapping]
Phosphatidate phosphatase LPIN3
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 270 aa
29.9 kDa 		No 0
LPIN3-005
ENSP00000487971
ENST00000632009
Q9BQK8 [Direct mapping]
Phosphatidate phosphatase LPIN3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 852 aa
93.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.