Expression of SERINC3 in cancer - Summary - The Human Protein Atlas

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SERINC3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SERINC3
Gene description	Serine incorporator 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048116
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048116

GENE INFORMATION
Gene name	SERINC3 (HGNC Symbol)
Synonyms	AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
Description	Serine incorporator 3 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	44496221 - 44522109
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132824 (version 83.38)
Entrez gene	10955
UniProt	Q13530 (UniProt - Evidence at transcript level)
neXtProt	NX_Q13530
Antibodypedia	SERINC3 antibodies

PROTEIN BROWSER

SERINC3-001	SERINC3-002	SERINC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERINC3-001 ENSP00000340243 ENST00000342374	Q13530 [Direct mapping] Serine incorporator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0009597 [detection of virus] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] Show all	473 aa 52.6 kDa	Yes	>9
SERINC3-002 ENSP00000414197 ENST00000411544	Q5H936 [Direct mapping] Serine incorporator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	212 aa 23.4 kDa	No	3
SERINC3-201 ENSP00000255175 ENST00000255175	Q13530 [Direct mapping] Serine incorporator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0009597 [detection of virus] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] Show all	473 aa 52.6 kDa	Yes	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.