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CASP9

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GENERAL INFORMATION

Gene name

 CASP9

Gene description

 Caspase 9, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA001473
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001473 A-431 Mitochondria
HPA001473 U-251 MG Mitochondria

GENE INFORMATION

Gene name

 CASP9 (HGNC Symbol)

Synonyms

 APAF-3, ICE-LAP6, MCH6, PPP1R56

Description

 Caspase 9, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

 1

Cytoband

 p36.21

Chromosome location (bp)

 15490832 - 15526534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132906 (version 83.38)

Entrez gene

 842

UniProt

 P55211 (UniProt - Evidence at protein level)

neXtProt

 NX_P55211

Antibodypedia

 CASP9 antibodies

PROTEIN BROWSER
CASP9-001
CASP9-002
CASP9-003
CASP9-004
CASP9-005
CASP9-007
CASP9-008
CASP9-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP9-001
ENSP00000330237
ENST00000333868
P55211 [Direct mapping]
Caspase-9 Caspase-9 subunit p35 Caspase-9 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007568 [aging]
GO:0008047 [enzyme activator activity]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0009411 [response to UV]
GO:0012501 [programmed cell death]
GO:0014070 [response to organic cyclic compound]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030220 [platelet formation]
GO:0032025 [response to cobalt ion]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0034349 [glial cell apoptotic process]
GO:0034644 [cellular response to UV]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043293 [apoptosome]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046677 [response to antibiotic]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 416 aa
46.3 kDa 		No 0
CASP9-002
ENSP00000255256
ENST00000348549
P55211 [Direct mapping]
Caspase-9 Caspase-9 subunit p35 Caspase-9 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008047 [enzyme activator activity]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030220 [platelet formation]
GO:0034644 [cellular response to UV]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043293 [apoptosome]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 266 aa
30.2 kDa 		No 0
CASP9-003
ENSP00000396540
ENST00000447522
Q5JRU2 [Direct mapping]
Caspase-9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 266 aa
28.8 kDa 		No 0
CASP9-004
ENSP00000480785
ENST00000469637
A0A087WX72 [Direct mapping]
Caspase-9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 47 aa
5.4 kDa 		No 0
CASP9-005
ENSP00000411304
ENST00000440484
Q5JRU8 [Direct mapping]
Caspase-9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 254 aa
28.4 kDa 		No 0
CASP9-007
ENSP00000408691
ENST00000424908
H0Y6Y2 [Direct mapping]
Caspase-9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 198 aa
21.8 kDa 		No 0
CASP9-008
ENSP00000365051
ENST00000375890
P55211 [Direct mapping]
Caspase-9 Caspase-9 subunit p35 Caspase-9 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008047 [enzyme activator activity]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030220 [platelet formation]
GO:0034644 [cellular response to UV]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043293 [apoptosome]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 333 aa
36.6 kDa 		No 0
CASP9-009
ENSP00000449584
ENST00000546424
F8VVS7 [Direct mapping]
Caspase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 421 aa
46.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.