Cell atlas - POMP - The Human Protein Atlas

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POMP

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POMP
Gene description	Proteasome maturation protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026995
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026995	A-431	Nuclear speckles
	HPA026995	U-2 OS	Nuclear speckles
	HPA026995	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	POMP (HGNC Symbol)
Synonyms	C13orf12, HSPC014, UMP1
Description	Proteasome maturation protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010]
Chromosome	13
Cytoband	q12.3
Chromosome location (bp)	28659104 - 28678925
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132963 (version 83.38)
Entrez gene	51371
UniProt	Q9Y244 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y244
Antibodypedia	POMP antibodies

PROTEIN BROWSER

POMP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POMP-001 ENSP00000370222 ENST00000380842	Q9Y244 [Direct mapping] Proteasome maturation protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0031090 [organelle membrane] GO:0043248 [proteasome assembly] Show all	141 aa 15.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.