Cell atlas - CDK8 - The Human Protein Atlas

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CDK8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDK8
Gene description	Cyclin-dependent kinase 8
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044721
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044721	BJ	Nucleus
	HPA044721	CACO-2	Nucleoplasm
	HPA044721	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	CDK8 (HGNC Symbol)
Synonyms	K35
Description	Cyclin-dependent kinase 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.13
Chromosome location (bp)	26254104 - 26405238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132964 (version 83.38)
Entrez gene	1024
UniProt	P49336 (UniProt - Evidence at protein level)
neXtProt	NX_P49336
Antibodypedia	CDK8 antibodies

PROTEIN BROWSER

CDK8-001	CDK8-005	CDK8-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK8-001 ENSP00000370938 ENST00000381527	P49336 [Direct mapping] Cyclin-dependent kinase 8 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010467 [gene expression] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] Show all	464 aa 53.3 kDa	No	0
CDK8-005 ENSP00000487013 ENST00000465820	A0A0D9SFZ2 [Direct mapping] Cyclin-dependent kinase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	196 aa 22.3 kDa	No	0
CDK8-006 ENSP00000485883 ENST00000625988	A0A0D9SEP3 [Direct mapping] Cyclin-dependent kinase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	148 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.