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WASF3

GENERAL INFORMATION

Gene name

 WASF3

Gene description

 WAS protein family, member 3

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB037086
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB037086

GENE INFORMATION

Gene name

 WASF3 (HGNC Symbol)

Synonyms

 KIAA0900, SCAR3, WAVE3

Description

 WAS protein family, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Chromosome

 13

Cytoband

 q12.13

Chromosome location (bp)

 26557703 - 26688948

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132970 (version 83.38)

Entrez gene

 10810

UniProt

 Q9UPY6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPY6

Antibodypedia

 WASF3 antibodies

PROTEIN BROWSER
WASF3-001
WASF3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WASF3-001
ENSP00000335055
ENST00000335327
Q9UPY6 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 3
Q5T8P4 [Target identity:100%; Query identity:100%]
WAS protein family, member 3, isoform CRA_b; cDNA FLJ76648, highly similar to Homo sapiens WAS protein family, member 3 (WASF3), mRNA
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0014003 [oligodendrocyte development]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030041 [actin filament polymerization]
GO:0031643 [positive regulation of myelination]
GO:0070062 [extracellular exosome]
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 502 aa
55.3 kDa 		No 0
WASF3-201
ENSP00000354325
ENST00000361042
Q9UPY6 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 3
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0030041 [actin filament polymerization]
GO:0070062 [extracellular exosome]
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 499 aa
55 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.