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CHRM3

GENERAL INFORMATION

Gene name

 CHRM3

Gene description

 Cholinergic receptor, muscarinic 3

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SH-SY5Y, U-266/70)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024106
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024106

GENE INFORMATION

Gene name

 CHRM3

Synonyms

Description

 Cholinergic receptor, muscarinic 3 (HGNC Symbol)

Entrez gene summary

 The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 239386565 - 239915452

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133019 (version 83.38)

Entrez gene

 1131

UniProt

 P20309 (UniProt - Evidence at protein level)

neXtProt

 NX_P20309

Antibodypedia

 CHRM3 antibodies

PROTEIN BROWSER
CHRM3-001
CHRM3-002
CHRM3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRM3-001
ENSP00000255380
ENST00000255380
P20309 [Direct mapping]
Muscarinic acetylcholine receptor M3
A0A024R3S2 [Target identity:100%; Query identity:100%]
Muscarinic acetylcholine receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003056 [regulation of vascular smooth muscle contraction]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006464 [cellular protein modification process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007399 [nervous system development]
GO:0007586 [digestion]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008144 [drug binding]
GO:0008283 [cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0019229 [regulation of vasoconstriction]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032279 [asymmetric synapse]
GO:0042166 [acetylcholine binding]
GO:0043679 [axon terminus]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046541 [saliva secretion]
GO:0050796 [regulation of insulin secretion]
Show all
 590 aa
66.1 kDa 		No 7
CHRM3-002
ENSP00000404764
ENST00000448020
B1AN12 [Direct mapping]
Muscarinic acetylcholine receptor M3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003056 [regulation of vascular smooth muscle contraction]
GO:0005887 [integral component of plasma membrane]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007606 [sensory perception of chemical stimulus]
GO:0016021 [integral component of membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0045202 [synapse]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046541 [saliva secretion]
Show all
 110 aa
11.8 kDa 		No 1
CHRM3-201
ENSP00000482377
ENST00000615928
P20309 [Direct mapping]
Muscarinic acetylcholine receptor M3
A0A024R3S2 [Target identity:100%; Query identity:100%]
Muscarinic acetylcholine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003056 [regulation of vascular smooth muscle contraction]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006464 [cellular protein modification process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007399 [nervous system development]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008283 [cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0030054 [cell junction]
GO:0042166 [acetylcholine binding]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046541 [saliva secretion]
GO:0050796 [regulation of insulin secretion]
Show all
 590 aa
66.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.