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CCNA1

GENERAL INFORMATION

Gene name

 CCNA1

Gene description

 Cyclin A1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer, ovarian cancer)
HPA (cell line):Cell line enhanced (HMC-1, U-937)
HPA (normal tissue):Tissue enhanced (parathyroid gland, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer, ovarian cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CCNA1 (HGNC Symbol)

Synonyms

 CT146

Description

 Cyclin A1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 36431520 - 36442882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133101 (version 83.38)

Entrez gene

 8900

UniProt

 P78396 (UniProt - Evidence at protein level)

neXtProt

 NX_P78396

Antibodypedia

 CCNA1 antibodies

PROTEIN BROWSER
CCNA1-001
CCNA1-002
CCNA1-003
CCNA1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNA1-001
ENSP00000255465
ENST00000255465
P78396 [Direct mapping]
Cyclin-A1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0015630 [microtubule cytoskeleton]
GO:0051301 [cell division]
Show all
 465 aa
52.4 kDa 		No 0
CCNA1-002
ENSP00000400666
ENST00000440264
P78396 [Direct mapping]
Cyclin-A1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0015630 [microtubule cytoskeleton]
GO:0051301 [cell division]
Show all
 421 aa
47.5 kDa 		No 0
CCNA1-003
ENSP00000486017
ENST00000625767
P78396 [Direct mapping]
Cyclin-A1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0015630 [microtubule cytoskeleton]
GO:0051301 [cell division]
Show all
 464 aa
52.2 kDa 		No 0
CCNA1-004
ENSP00000486482
ENST00000630422
P78396 [Direct mapping]
Cyclin-A1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0015630 [microtubule cytoskeleton]
GO:0051301 [cell division]
Show all
 421 aa
47.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.