Expression of POSTN in cancer - Summary - The Human Protein Atlas

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POSTN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	POSTN
Gene description	Periostin, osteoblast specific factor
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (U-138 MG, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in extracellular matrix.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA012306
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012306

GENE INFORMATION
Gene name	POSTN (HGNC Symbol)
Synonyms	OSF-2, periostin, PN
Description	Periostin, osteoblast specific factor (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	37562583 - 37598844
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133110 (version 83.38)
Entrez gene	10631
UniProt	Q15063 (UniProt - Evidence at protein level)
neXtProt	NX_Q15063
Antibodypedia	POSTN antibodies

PROTEIN BROWSER

POSTN-001	POSTN-002	POSTN-003	POSTN-004	POSTN-201	POSTN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POSTN-001 ENSP00000369071 ENST00000379747	Q15063 [Direct mapping] Periostin A0A024RDS2 [Target identity:100%; Query identity:100%] Periostin, osteoblast specific factor, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001666 [response to hypoxia] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003073 [regulation of systemic arterial blood pressure] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005802 [trans-Golgi network] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0008593 [regulation of Notch signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0009888 [tissue development] GO:0014850 [response to muscle activity] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0031594 [neuromuscular junction] GO:0032355 [response to estradiol] GO:0042060 [wound healing] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050839 [cell adhesion molecule binding] GO:0071356 [cellular response to tumor necrosis factor] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading] GO:1904209 [positive regulation of chemokine (C-C motif) ligand 2 secretion] GO:1990138 [neuron projection extension] GO:1990523 [bone regeneration] Show all	836 aa 93.3 kDa	Yes	0
POSTN-002 ENSP00000369066 ENST00000379742	Q15063 [Direct mapping] Periostin A0A024RDT5 [Target identity:100%; Query identity:100%] Periostin, osteoblast specific factor, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0050839 [cell adhesion molecule binding] Show all	779 aa 87 kDa	Yes	0
POSTN-003 ENSP00000369067 ENST00000379743	Q15063 [Direct mapping] Periostin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0050839 [cell adhesion molecule binding] Show all	809 aa 90.4 kDa	Yes	0
POSTN-004 ENSP00000369073 ENST00000379749	B1ALD9 [Direct mapping] Periostin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0030198 [extracellular matrix organization] GO:0050839 [cell adhesion molecule binding] Show all	808 aa 90.1 kDa	Yes	0
POSTN-201 ENSP00000437959 ENST00000541179	Q15063 [Direct mapping] Periostin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0050839 [cell adhesion molecule binding] Show all	781 aa 87.3 kDa	Yes	0
POSTN-202 ENSP00000437953 ENST00000541481	Q15063 [Direct mapping] Periostin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0050839 [cell adhesion molecule binding] Show all	749 aa 83.5 kDa	Yes	0

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