Expression of TPT1 in cancer - Summary - The Human Protein Atlas

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TPT1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TPT1
Gene description	Tumor protein, translationally-controlled 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA039437 , CAB008364
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (favourable), breast cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Breast cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039437	CAB008364

GENE INFORMATION
Gene name	TPT1 (HGNC Symbol)
Synonyms	fortilin, TCTP
Description	Tumor protein, translationally-controlled 1 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q14.13
Chromosome location (bp)	45333471 - 45341370
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133112 (version 83.38)
Entrez gene	7178
UniProt	P13693 (UniProt - Evidence at protein level)
neXtProt	NX_P13693
Antibodypedia	TPT1 antibodies

PROTEIN BROWSER

TPT1-001	TPT1-002	TPT1-003	TPT1-004	TPT1-008	TPT1-009	TPT1-011	TPT1-012	TPT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPT1-001 ENSP00000431872 ENST00000530705	P13693 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0009615 [response to virus] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0045298 [tubulin complex] GO:0070062 [extracellular exosome] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] Show all	172 aa 19.6 kDa	No	0
TPT1-002 ENSP00000368345 ENST00000379056	P13693 [Direct mapping] Translationally-controlled tumor protein A0A024RDY2 [Target identity:100%; Query identity:100%] Tumor protein, translationally-controlled 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0009615 [response to virus] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0045298 [tubulin complex] GO:0070062 [extracellular exosome] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] Show all	138 aa 15.6 kDa	No	0
TPT1-003 ENSP00000368344 ENST00000379055	P13693 [Direct mapping] Translationally-controlled tumor protein A0A024RDY2 [Target identity:100%; Query identity:100%] Tumor protein, translationally-controlled 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0009615 [response to virus] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0045298 [tubulin complex] GO:0070062 [extracellular exosome] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] Show all	138 aa 15.6 kDa	No	0
TPT1-004 ENSP00000339051 ENST00000309246	Q5W0H4 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	188 aa 21.5 kDa	No	0
TPT1-008 ENSP00000433091 ENST00000528619	H0YCX0 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 9 kDa	No	0
TPT1-009 ENSP00000432457 ENST00000530245	H0YCX0 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 9 kDa	No	0
TPT1-011 ENSP00000368350 ENST00000379060	J3KPG2 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	160 aa 18.1 kDa	No	0
TPT1-012 ENSP00000433738 ENST00000527226	E9PJF7 [Direct mapping] Translationally-controlled tumor protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	162 aa 18.2 kDa	No	0
TPT1-201 ENSP00000477781 ENST00000616577	A0A0B4J2C3 [Direct mapping] Translationally-controlled tumor protein; Tumor protein, translationally-controlled 1, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0008134 [transcription factor binding] GO:0019827 [stem cell population maintenance] GO:2000384 [negative regulation of ectoderm development] Show all	197 aa 22.6 kDa	No	0

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