Expression of STOML3 in cancer - Summary - The Human Protein Atlas

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STOML3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STOML3
Gene description	Stomatin (EPB72)-like 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enriched (AF22)
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, distinct expression in endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA012892 , CAB014880
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012892	CAB014880

GENE INFORMATION
Gene name	STOML3 (HGNC Symbol)
Synonyms	Epb7.2l, SRO
Description	Stomatin (EPB72)-like 3 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	38965925 - 38991066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133115 (version 83.38)
Entrez gene	161003
UniProt	Q8TAV4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TAV4
Antibodypedia	STOML3 antibodies

PROTEIN BROWSER

STOML3-001	STOML3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STOML3-001 ENSP00000368952 ENST00000379631	Q8TAV4 [Direct mapping] Stomatin-like protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007165 [signal transduction] GO:0008150 [biological_process] GO:0045121 [membrane raft] Show all	291 aa 32.1 kDa	No	1
STOML3-201 ENSP00000401989 ENST00000423210	Q8TAV4 [Direct mapping] Stomatin-like protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] Show all	282 aa 31 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.