Cell atlas - IRS4 - The Human Protein Atlas

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IRS4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	IRS4
Gene description	Insulin receptor substrate 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HEK 293, RT4, WM-115)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, RT4, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	IRS4 (HGNC Symbol)
Synonyms	IRS-4, PY160
Description	Insulin receptor substrate 4 (HGNC Symbol)
Entrez gene summary	IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	108732482 - 108736409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133124 (version 83.38)
Entrez gene	8471
UniProt	O14654 (UniProt - Evidence at protein level)
neXtProt	NX_O14654
Antibodypedia	IRS4 antibodies

PROTEIN BROWSER

IRS4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRS4-001 ENSP00000361202 ENST00000372129	O14654 [Direct mapping] Insulin receptor substrate 4 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0019216 [regulation of lipid metabolic process] GO:0043548 [phosphatidylinositol 3-kinase binding] Show all	1257 aa 133.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.