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Ring finger protein 128, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GO:0005515 [protein binding] GO:0005770 [late endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005856 [cytoskeleton] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0031647 [regulation of protein stability] GO:0042036 [negative regulation of cytokine biosynthetic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0061462 [protein localization to lysosome] GO:0061630 [ubiquitin protein ligase activity] GO:1904352 [positive regulation of protein catabolic process in the vacuole]
GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0031647 [regulation of protein stability] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0061462 [protein localization to lysosome] GO:0061630 [ubiquitin protein ligase activity] GO:1904352 [positive regulation of protein catabolic process in the vacuole]
