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SRRM1

GENERAL INFORMATION

Gene name

 SRRM1

Gene description

 Serine/arginine repetitive matrix 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA049941
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049941

GENE INFORMATION

Gene name

 SRRM1 (HGNC Symbol)

Synonyms

 MGC39488, POP101, SRM160

Description

 Serine/arginine repetitive matrix 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 24631716 - 24673267

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133226 (version 83.38)

Entrez gene

 10250

UniProt

 Q8IYB3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYB3

Antibodypedia

 SRRM1 antibodies

PROTEIN BROWSER
SRRM1-001
SRRM1-002
SRRM1-022
SRRM1-024
SRRM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRRM1-001
ENSP00000326261
ENST00000323848
Q8IYB3 [Direct mapping]
Serine/arginine repetitive matrix protein 1
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
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 904 aa
102.3 kDa 		No 0
SRRM1-002
ENSP00000363510
ENST00000374389
A9Z1X7 [Direct mapping]
Serine/arginine repetitive matrix protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
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 913 aa
103.4 kDa 		No 0
SRRM1-022
ENSP00000471084
ENST00000596378
M0R088 [Direct mapping]
Serine/arginine repetitive matrix protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
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 681 aa
78.1 kDa 		No 0
SRRM1-024
ENSP00000469151
ENST00000593639
M0QXG5 [Direct mapping]
Serine/arginine repetitive matrix protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006397 [mRNA processing]
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 102 aa
11.8 kDa 		No 0
SRRM1-201
ENSP00000391430
ENST00000447431
E9PCT1 [Direct mapping]
Serine/arginine repetitive matrix protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
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 820 aa
93.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.