Expression of ZNF414 in cancer - Summary - The Human Protein Atlas

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ZNF414

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF414
Gene description	Zinc finger protein 414
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053769
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), endometrial cancer (favourable), pancreatic cancer (favourable) and urothelial cancer (favourable).
Head and neck cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053769

GENE INFORMATION
Gene name	ZNF414 (HGNC Symbol)
Synonyms	MGC15716, Zfp414
Description	Zinc finger protein 414 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8509678 - 8514164
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133250 (version 83.38)
Entrez gene	84330
UniProt	Q96IQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IQ9
Antibodypedia	ZNF414 antibodies

PROTEIN BROWSER

ZNF414-001	ZNF414-002	ZNF414-003	ZNF414-007	ZNF414-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF414-001 ENSP00000377504 ENST00000393927	Q96IQ9 [Direct mapping] Zinc finger protein 414 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	390 aa 41 kDa	No	0
ZNF414-002 ENSP00000255616 ENST00000255616	Q96IQ9 [Direct mapping] Zinc finger protein 414 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	312 aa 32.8 kDa	No	0
ZNF414-003 ENSP00000471378 ENST00000596772	M0R0Q5 [Direct mapping] Zinc finger protein 414 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 12 kDa	No	0
ZNF414-007 ENSP00000473079 ENST00000593661	M0R398 [Direct mapping] Zinc finger protein 414 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 18.2 kDa	No	0
ZNF414-008 ENSP00000471863 ENST00000594748	M0R1G8 [Direct mapping] Zinc finger protein 414 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 16.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.