Fields »
ABOUT
HELP
BLOG
LGALS12

GENERAL INFORMATION

Gene name

 LGALS12

Gene description

 Lectin, galactoside-binding, soluble, 12

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HL-60, NB-4, U-937)
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 LGALS12 (HGNC Symbol)

Synonyms

 GRIP1

Description

 Lectin, galactoside-binding, soluble, 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 63506084 - 63516774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133317 (version 83.38)

Entrez gene

 85329

UniProt

 Q96DT0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DT0

Antibodypedia

 LGALS12 antibodies

PROTEIN BROWSER
LGALS12-001
LGALS12-002
LGALS12-003
LGALS12-004
LGALS12-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LGALS12-001
ENSP00000378116
ENST00000394618
Q96DT0 [Direct mapping]
Galectin-12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 336 aa
37.5 kDa 		No 0
LGALS12-002
ENSP00000339374
ENST00000340246
Q96DT0 [Direct mapping]
Galectin-12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 337 aa
37.6 kDa 		No 0
LGALS12-003
ENSP00000255684
ENST00000255684
Q96DT0 [Direct mapping]
Galectin-12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 327 aa
36.5 kDa 		No 0
LGALS12-004
ENSP00000394659
ENST00000415491
Q96DT0 [Direct mapping]
Galectin-12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 275 aa
31 kDa 		No 0
LGALS12-005
ENSP00000399093
ENST00000425950
Q96DT0 [Direct mapping]
Galectin-12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 266 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.